KMID : 0616120080390020086
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Korean Journal of Pharmacognosy 2008 Volume.39 No. 2 p.86 ~ p.90
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Cognitive-enhancing activity of decursin derivatives
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Lee Ki-Yong
Kim Young-Choong Sung Sang-Hyun
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Abstract
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Two decursin derivatives were synthesized from decursinol. Compounds 1 and 2 were determined as 7-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy}-8,8-dimethyl-7,8-dihydro-6H-pyranochromen-2-one (1) and decursinol 3¡¯-O-E-pmethoxycinnamic acid ester (2), respectively and newly reported. Compounds 1 and 2 significantly inhibited AChE activity and ameliorated memory impairment induced in mice by scopolamine (1.0 mg/kg body weight s.c.) as measured in passive avoidance test. We suggest, therefore, that compounds 1 and 2 has both anti-AChE and anti-amnesic activities that may ultimately hold significant therapeutic value in alleviating certain memory impairment observed in Alzheimer¡¯s disease.
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KEYWORD
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Decursin, 7-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy}-8, 8-dimethyl-7, 8-dihydro-6H-pyranochromen-
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